Angioedema; severe aortic stenosis; intravascularly vol depleted patients (eg, those treated w/ diuretics); impaired hepatic function or progressive liver disease. Amlodipine: Severe obstructive coronary artery disease. Hydrochlorothiazide: Exacerbation or activation of SLE. Concomitant use w/ lithium. Signs of fluid or electrolyte imbalance. Severe renal disease. May precipitate azotemia in patients w/ renal disease. Losartan: Discontinue use when pregnancy is detected.
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